Denzel Washington

Lincoln Rhyme

Angelina Jolie

Amelia Donaghy

Queen Latifah

Thelma

Michael Rooker

Captain Howard Cheney

Michael McGlone

Detective Kenny Solomon

Luis Guzmán

Eddie Ortiz

Leland Orser

Richard Thompson

John Benjamin Hickey

Dr. Barry Lehman

Bobby Cannavale

Steve, Amelia's Boyfriend

Ed O'Neill

Detective Paulie Sellitto

Richard Zeman

Lieutenant Carl Hanson

Olivia Birkelund

Lindsay Rubin

Gary Swanson

Alan Rubin

James Bulleit

Train Engineer

Frank Fontaine

Grandfather

Zena Grey

Granddaughter

Daniel Brochu

NYU Student

Desmond Campbell

Taxi Inspector

Christian Veliz

Young Boy

Mercedes Gómez

Ortiz's Mother

Mary C. Hammett

Girlfriend in Nightclub

Amanda Gay

Girl in Nightclub

Steve Adams

Gas Worker

Larry Day

Gas Worker

Burke Lawrence

Police Instructor

Terry Simpson

Cop in Apartment

Eric Davis

Cop in Apartment

Arthur Holden

Bookstore Clerk

Yahsmin Daviault

Rhyme's Sister

Keenan MacWilliam

Rhyme's Niece

David Warshofsky

Amelia's Partner

Mateo Gómez

Hot Dog Vendor

Ted Whittall

Ortiz's Assistant

Peter Michael Dillon

Homicide Detective

Jonathan Stark

Male Detective

Fulvio Cecere

Forensics Expert

Hal Sherman

Fingerprint Cop

Russell Yuen

Forensics Worker

Andy Bradshaw

Uniform Cop

Jean-Marc Bisson

Rescue Worker

Christopher Bregman

Rescue Worker

Sonya Biddle

Nurse

Phillip Noyce

Customer in Antique Bookshop (uncredited)

Charles Alonso

News Reporter (uncredited)

Michael Arthur

NYPD Officer (uncredited)

Alex Lorre

Rescue Worker (uncredited)

Todo Segalla

Cop (uncredited)

Andrew Semple

Perp (uncredited)