Michael C. Hall

Jack

Sarah Silverman

Cheri

Rainn Wilson

Joel

Ben Schwartz

Nathan

Kate Mara

Meg

Taraji P. Henson

Mary

Judy Greer

Laura

Alicia Witt

Amy

Ron Rifkin

Henry Meyerwitz

Lesley Ann Warren

Marilyn

Octavia Spencer

Alison

Rich Delia

Waiter

Stephen Tobolowsky

Ephraim

Lewis Black

Narrator (voice)

Kulap Vilaysack

Lily

Niko Novick

Paramedic (uncredited)

Nicholas Hormann

Ted

Michael McDonald

British Director

Troian Bellisario

Film Set P.A.

David Packer

Eli

Danay García

Attractive P.A.

Deborah Pratt

Cassandra Williamson

Michael Cavanaugh

Brad Thompkins

Michael Chinyamurindi

Maduk

Paige Orr

Carly

Geoffrey Arend

Dr. Novak

Dominic Flores

Salvador

Guillermo Díaz

Jesus

Lester Speight

Wizdom

Jack Plotnick

Bookstore Manager

Emily Kuroda

Nail Salon Owner

Jeff Lam

Chun

Karl Stavem

Paul the Maitre d'

David Diaan

Hari

Raja Fenske

Rajeev

Sam Carson

Man in Booth

Tom Katsis

Henry's Friend

Rita Rani Ahuja

Doctor