Peter Dinklage

Winston Gooze / Toxie (Voice)

Jacob Tremblay

Wade Gooze

Kevin Bacon

Bob Garbinger

Elijah Wood

Fritz Garbinger

Taylour Paige

J.J. Doherty

Julia Davis

Kissy Sturnevan

Sarah Niles

Mayor Togar

Jonny Coyne

Thad Barkabus

Macon Blair

Dennis

Atanas Srebrev

Chief Wormer

Abraham Lewis

Spence

Lee Eddy

CJ Doons

Spencer Wilding

Monster Garbinger

Annette Badland

Daisy

Sunil Patel

Dr. Walla

Rebecca O'Mara

Shelly Gooze

Lloyd Kaufman

Lloyd (The Hospital Grump)

Chris Sharp

C.S. Hawley

Shaun Dooley

Mel Ferd

Brent Werzner

Toxie Witness

Randy E. Aguebor

Coach Stanwyck

Ev Lunning

Rick Feet

David Yow

Guthrie Stockins

Jane Levy

Cheerful Insurance Rep (voice)

Luisa Guerreiro

Toxic Avenger/Toxie