Missi Pyle

Lucy

Melissa McCarthy

Becky

Josh Hopkins

George

Octavia Spencer

Mary

Jack Noseworthy

Trevor

Larry Sullivan

Austin

Allison Janney

Suzanna

Phill Lewis

Raye

William Sanderson

Sam

Allison Mackie

Bitter Flight Attendant

Amy Landers

Puffy Paint Flight Attendant

Ben Falcone

Coach Merryweather

Tate Taylor

George's Boyfriend

Philip Littell

Richard

Stacy Yutuc

Flirty Flight Attendant

Drew Matthews

Boy

Sean Daly

Park Ranger

Brutus

Bear

Wyatt Earp

Airport Announcer (voice)