Chiranjeevi

Shankar Prasad / Shankar Dada

Srikanth

ATM

Sonali Bendre

Dr. Sunitha "Chitti"

Paresh Rawal

Dr. J. Rama Lingeshwara Rao

Girish Karnad

Satya Prasad

Vennira Aadai Nirmala

Shankar Prasad's mother

M. S. Narayana

Dr. Chidambaram MBBS, FRCS

Surya Bhagawan Das

Dr. Mohammed Rafi

Deepti Nallamothu

Meena

Sharwanand

Vijay

Panja Vaisshnav Tej

Cameo Appearance as Child Artist

Ali Basha

Thief

Ahuti Prasad

Corrupted Doctor

Gauahar Khan

Special appearance in song

Venu Madhav

Malhotra, Shankar's henchmen

Tirupati Prakash

Chalapathi Rao

Bhupinder Singh

Pandu Dada

Banerjee

Corrupted Faculty

Narsing Yadav

Shankar's henchmen

Thotapalli Madhu

Athili Lakshmi

Duvvasi Mohan

Karate Kalyani Padala

Anjala Zaveri

Cameo Appearance in “Chaila Chaila” song

Gauahar Khan

Special appearance in the song "Naa Pera Kanchan Mala"

Pawan Kalyan

Special appearance in song